Digestive Health Irritable Bowel Syndrome The Role Dysbiosis May Be Playing in Your Health By Barbara Bolen, PhD Barbara Bolen, PhD Twitter Barbara Bolen, PhD, is a licensed clinical psychologist and health coach. She has written multiple books focused on living with irritable bowel syndrome. Learn about our editorial process Updated on October 23, 2020 Learn more</a>." data-inline-tooltip="true"> Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Priyanka Chugh, MD Medically reviewed by Priyanka Chugh, MD LinkedIn Priyanka Chugh, MD, is a board-certified gastroenterologist in practice with Trinity Health of New England in Waterbury, Connecticut. Learn about our Medical Review Board Print Dysbiosis is a state in which there is an imbalance of microorganisms on or within our bodies. When in balance, these colonies of microorganisms tend to have a favorable effect on our bodies. When there is an imbalance, we may experience unwanted symptoms. jamesbenet/E+/Getty Images Overview Gut microbiota dysbiosis, also known as intestinal or gastrointestinal dysbiosis, refers to a condition in which there is an imbalance of the microorganisms within our intestines. These microorganisms, collectively known as gut flora, consist predominantly of various strains of bacteria, and to a lesser extent include fungi and protozoa. The gut flora are essential for digestion and immune functioning. A state of dysbiosis, therefore, will result in digestive and other systemic symptoms. Health Problems Stemming From Gut Dysbiosis Dysbiosis has been identified as playing a possible role with a variety of health problems. What this role might be is not always clear. It is theorized that the balance of gut bacteria can affect the immune system and the health of the lining of the gut (increased intestinal permeability). As you can see, health conditions in which dysbiosis might play a part are not all digestive in nature: Inflammatory bowel disease (IBD) Irritable bowel syndrome (IBS) Obesity Metabolic syndrome Type 2 diabetes Ankylosing spondylitis Atopic eczema Rheumatoid arthritis Causes Dysbiosis reflects a change in the population of the various microbes, in that unhelpful microbes overpower those that are more beneficial. Unfortunately, this tends to have a snowball effect, as the lesser amounts of helpful microbes become less and less able to keep the "unfriendly" microbes from multiplying. Dysbiosis may also be the result of a change in the location of the various types of microorganisms throughout the intestines or a change in how they are operating. Some factors that appear contribute to a state of dysbiosis include: Antibiotic use (from medications or from the consumption of antibiotic-treated animal products)Unhealthy diet (lacking in nutrients and fiber or containing harmful substances)Alcohol abuseSecondary to medical illness, such as chemotherapy for cancerHigh life stress levels Improving Gut Health Dysbiosis can theoretically be improved through improved dietary and lifestyle habits, such as eating a balanced, nutritious diet and engaging in mind/body techniques for stress management. Some alternative health practitioners recommend the use of bone broth, but there is no clinical research to back up this recommendation. The research on the relationship between gut dysbiosis and our health is still in preliminary stages, although it is rapidly expanding. As of now, there are several treatment options that have received some research support for improving a state of dysbiosis: Probiotics Prebiotics Fecal microbiota transplantation For people who have irritable bowel syndrome, there is a specific antibiotic named Xifaxan (rifaximin) that targets dysbiosis in the intestines. As of now, this area of medicine is still in its preliminary stages. Clear information about improving dysbiosis and what effect that will have on health disorders are not yet available. However, this area of inquiry appears to be a promising one. Was this page helpful? Thanks for your feedback! One of the most challenging aspects of having IBS is trying to figure out what's safe to eat. Our recipe guide makes it easier. Sign up and get yours now! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 10 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Belizário JE, Faintuch J, Garay-Malpartida M. Gut microbiome dysbiosis and immunometabolism: New frontiers for treatment of metabolic diseases. Mediators Inflamm. 2018;2018:2037838. doi:10.1155/2018/2037838 Belizário JE, Faintuch J. Microbiome and gut dysbiosis. Exp Suppl. 2018;109:459-476. doi:10.1007/978-3-319-74932-7_13 Zhang L, Hu Y, Xu Y, et al. The correlation between intestinal dysbiosis and the development of ankylosing spondylitis. Microb Pathog. 2019;132:188-192. doi:10.1016/j.micpath.2019.04.038 Lee SY, Lee E, Park YM, Hong SJ. Microbiome in the gut-skin axis in atopic dermatitis. 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